Event ID 5003:
"Unable to initialize the Information Store service because the clocks on the client and server are skewed. This may be caused by a time change either on the client or on the server, and may require a restart of that computer. Verify that your domain is correctly configured and is currently online."
Problem Cause : The clocks on the client and server are skewed. Make sure the clock in your system tray shows the same time/date for both the Exchange server and the domain controllers.
Solution :
Make sure the clock in your system tray shows the same time/date for both the Exchange server and the domain controllers.
Use the following command
Net time \\ADServerName /Set
and then you need to restart the service
Microsoft Exchange Active Directory Topology Service
Source in here
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